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Picosecond laser treatment more effective than hydroquinone alone for melasma

Picosecond laser treatment more effective than hydroquinone alone for melasma

A treatment strategy combining picosecond laser using 1064 nm and 595 nm wavelengths and topical hydroquinone (HQ) was reported to be effective and safe for the treatment of melasma, according to a recent study from Korea.

In the prospective, randomized, split-face, controlled trial, the laser treatment strategy in combination with 2 percent topical HQ was more effective than 2 percent HQ alone in terms of achieving ≥51 percent improvement of relative lightness values (RL*I) (76.92 vs 2.56 percent). [Lasers Surg Med 2017,  doi:10.1002/lsm.22735]

Colour change was also more marked in the laser treatment plus HQ group vs HQ alone (p<0.0001).

Subjective satisfaction assessment indicated that more patients were satisfied with the combination treatment vs HQ only (58.97 vs 15.37 percent; p<0.0005).

Adverse events were experienced by 5 percent of patients receiving laser treatment plus HQ, and included mild dermatitis following the procedure, mild pain during the treatment and transient erythema.

HQ and chemical peels with glycolic and salicylic acid are commonly used for melasma treatment, but they offer no therapeutic effect for dermal and mixed-type melasma.

Laser- and light-based treatments have mainly been applied to patients with moderate-to-severe melasma. The low-fluence 1,064 nm Q-switched Nd:YAG laser is the most widely used treatment procedure for Asians with dermal or mixed-type melasma. This treatment modality, however, results in high risk of recurrence and postinflammatory hyperpigmentation (PIH).

Picosecond lasers are based on the same treatment principle as nanosecond lasers, but it enables reduction of photothermal effect with increase in photomechanical effect. Reduction of photothermal effect and the total duration of the procedure will help reduce the occurrence of adverse events such as PIH.

Melasma is a condition where melanocytes are abnormally activated due to various factors, such as ultraviolet light exposure, hormonal influences and genetic predisposition.


The above information is not medical advice, for reference only / from : Michelle




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